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中国癌症防治杂志

中国癌症防治杂志 ›› 2013, Vol. 5 ›› Issue (3): 239-242.doi: 10.3969/j.issn.1674-5671.2013.03.11

• 临床研究 • 上一篇    下一篇

颅内肿瘤WHO分级与细胞免疫功能的关系

  

  1. 广西医科大学附属肿瘤医院头颈外科
  • 出版日期:2013-09-25 发布日期:2013-10-10
  • 通讯作者: 莫立根 E-mail:ligenmo@163.com

Correlation between the cellular immunity status and WHO classification of intracranial tumors

  • Online:2013-09-25 Published:2013-10-10

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摘要： 目的 检测颅内肿瘤患者外周血液细胞免疫功能，探讨细胞免疫功能与WHO颅内肿瘤分级的关系，为颅内肿瘤的综合治疗提供依据。方法 回顾研究2010年8月至2013年5月我科收治的79例颅内手术患者，应用流式细胞仪进行术前外周血液细胞免疫功能的检测，根据术后病理诊断明确肿瘤WHO分级。用Spearman等级相关分析法分析细胞免疫功能与肿瘤WHO分级的相关关系。结果 最终纳入研究共57例患者，经Spearman等级相关分析显示，CD3+、CD4+/CD8+、CD8+、CD16+ CD56 +及CD19+与颅内肿瘤WHO分级无相关（P＞0.05），CD4+与颅内肿瘤WHO分级呈低度负相关（r=-0.292，P＜0.05）。结论 颅内肿瘤WHO分级与细胞免疫功能无明显相关关系，有待进一步研究。

关键词:  , 脑肿瘤, 细胞免疫功能, 肿瘤WHO分级

Abstract: Objective To investigate whether the cellular immunity status of intracranial tumors correlates with their WHO classification. Methods In this retrospective analysis of 79 patients operated on for intracranial tumors between August 2010 and May 2013，flow cytometry was used to assess levels of various T cell populations in the tumor tissue，and the WHO classification of the tissue was determined by postoperative pathology.Possible correlations between T cell populations and WHO classification were investigated using Spearman′s rank correlation. Results In the final analysis of 57 patients， levels of T cells positive for CD3+，CD4+/CD8+，CD8+，CD16+ CD56+ and CD19+ did not correlate with WHO classification.However， the level of CD4+ T cells negatively correlated with WHO classification （P<0.05）. Conclusions In intracranial tumors，cellular immunity status does not significantly correlate with WHO classification.

Key words: Intracranial neoplasms, Cellular immunity, WHO classification